AustralieFrV1, Main, Exploration, bibRecord, 008C54

Influence of the ACE Gene Insertion/Deletion Polymorphism on Insulin Sensitivity and Impaired Glucose Tolerance in Healthy Subjects

Identifieur interne : 008C54 ( Main/Exploration ); précédent : 008C53; suivant : 008C55

Influence of the ACE Gene Insertion/Deletion Polymorphism on Insulin Sensitivity and Impaired Glucose Tolerance in Healthy Subjects

Auteurs : Fabrice Bonnet [France] ; Sheila Patel [Australie] ; Martine Laville [France] ; Beverley Balkau [France] ; Angela Favuzzi [Italie] ; Lucilla D. Monti [Italie] ; Nebojsa Lalic [Serbie] ; Mark Walker [Royaume-Uni]

Source :

Diabetes care [ 0149-5992 ] ; 2008.

RBID : Pascal:08-0258544

Descripteurs français

Pascal (Inist)
- Délétion, Polymorphisme, Génotype, Anomalie de la tolérance au glucose, Variabilité génétique, Insertion, Insuline, Individu sain, Endocrinologie, Maladie métabolique, Nutrition, Homme, Angiotensin converting enzyme, Sensibilité à l'insuline.
Wicri :
- topic : Nutrition, Homme.

English descriptors

KwdEn :
- Deletion, Endocrinology, Genetic variability, Genotype, Healthy subject, Human, Impaired glucose tolerance, Insertion, Insulin, Insulin sensitivity, Metabolic diseases, Nutrition, Polymorphism.

Abstract

OBJECTIVE ¯ Recent studies suggested that the blockade of the renin-angiotensin system (RAS) may be associated with metabolic benefits. However, data about the potential influence of the ACE insertion/deletion (I/D) genotype on insulin resistance have been contradictory with studies of limited sample sizes. The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects. RESEARCH DESIGN AND METHODS - A total of 1,286 participants in the Relationship Between Insulin Sensitivity and Cardiovascular Disease Risk Study had a 75-g oral glucose tolerance test and a hyperinsulinemic-euglycemic clamp to assess whole-body insulin sensitivity. RESULTS - Age, BMI, waist, fat-free mass (ffm), and physical activity did not differ by ACE genotype. Fasting glucose and insulin were similar among genotypes, but 2-h glucose levels were higher in DD than in ID and II subjects (DD: 5.9 ± 1.7; ID: 5.7 ± 1.5; II: 5.6 ± 1.5 mmol/l) (P = 0.004). Participants with the DD genotype were more likely to have impaired glucose tolerance than those with the ID and II genotypes (13.1 vs. 8.7%; P = 0.02). Insulin sensitivity was lower in participants with the DD genotype than in those with the II genotype (136 ± 63 vs. 147 ± 65 nmol . min^-1 kg ffm^-1 .mmol^-1 . 1^-1; P = 0.02). The presence of the D allele was associated with a trend, albeit not significant, for reduced insulin secretion during the oral glucose tolerance test (P = 0.07). CONCLUSIONS - The ACE I/D polymorphism is associated with whole-body insulin sensitivity and with impaired glucose tolerance in our healthy population. These findings confirm potential interactions between the RAS and glucose metabolism.

Affiliations:

Australie, France, Italie, Royaume-Uni, Serbie
Auvergne-Rhône-Alpes, Latium, Lombardie, Rhône-Alpes, Région Bretagne, Victoria (État)
Lyon, Melbourne, Milan, Orsay, Rennes, Rome
Université de Melbourne

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<series><title level="j" type="main">Diabetes care</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deletion</term>
<term>Endocrinology</term>
<term>Genetic variability</term>
<term>Genotype</term>
<term>Healthy subject</term>
<term>Human</term>
<term>Impaired glucose tolerance</term>
<term>Insertion</term>
<term>Insulin</term>
<term>Insulin sensitivity</term>
<term>Metabolic diseases</term>
<term>Nutrition</term>
<term>Polymorphism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Délétion</term>
<term>Polymorphisme</term>
<term>Génotype</term>
<term>Anomalie de la tolérance au glucose</term>
<term>Variabilité génétique</term>
<term>Insertion</term>
<term>Insuline</term>
<term>Individu sain</term>
<term>Endocrinologie</term>
<term>Maladie métabolique</term>
<term>Nutrition</term>
<term>Homme</term>
<term>Angiotensin converting enzyme</term>
<term>Sensibilité à l'insuline</term>
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<term>Homme</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE ¯ Recent studies suggested that the blockade of the renin-angiotensin system (RAS) may be associated with metabolic benefits. However, data about the potential influence of the ACE insertion/deletion (I/D) genotype on insulin resistance have been contradictory with studies of limited sample sizes. The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects. RESEARCH DESIGN AND METHODS - A total of 1,286 participants in the Relationship Between Insulin Sensitivity and Cardiovascular Disease Risk Study had a 75-g oral glucose tolerance test and a hyperinsulinemic-euglycemic clamp to assess whole-body insulin sensitivity. RESULTS - Age, BMI, waist, fat-free mass (ffm), and physical activity did not differ by ACE genotype. Fasting glucose and insulin were similar among genotypes, but 2-h glucose levels were higher in DD than in ID and II subjects (DD: 5.9 ± 1.7; ID: 5.7 ± 1.5; II: 5.6 ± 1.5 mmol/l) (P = 0.004). Participants with the DD genotype were more likely to have impaired glucose tolerance than those with the ID and II genotypes (13.1 vs. 8.7%; P = 0.02). Insulin sensitivity was lower in participants with the DD genotype than in those with the II genotype (136 ± 63 vs. 147 ± 65 nmol . min<sup>-1</sup>
 kg ffm<sup>-1</sup>
 .mmol<sup>-1</sup>
 . 1<sup>-1</sup>
; P = 0.02). The presence of the D allele was associated with a trend, albeit not significant, for reduced insulin secretion during the oral glucose tolerance test (P = 0.07). CONCLUSIONS - The ACE I/D polymorphism is associated with whole-body insulin sensitivity and with impaired glucose tolerance in our healthy population. These findings confirm potential interactions between the RAS and glucose metabolism.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Serbie</li>
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<region><li>Auvergne-Rhône-Alpes</li>
<li>Latium</li>
<li>Lombardie</li>
<li>Rhône-Alpes</li>
<li>Région Bretagne</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Lyon</li>
<li>Melbourne</li>
<li>Milan</li>
<li>Orsay</li>
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<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Région Bretagne"><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
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<name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name>
<name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name>
<name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<name sortKey="Laville, Martine" sort="Laville, Martine" uniqKey="Laville M" first="Martine" last="Laville">Martine Laville</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Patel, Sheila" sort="Patel, Sheila" uniqKey="Patel S" first="Sheila" last="Patel">Sheila Patel</name>
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<country name="Italie"><region name="Latium"><name sortKey="Favuzzi, Angela" sort="Favuzzi, Angela" uniqKey="Favuzzi A" first="Angela" last="Favuzzi">Angela Favuzzi</name>
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<country name="Serbie"><noRegion><name sortKey="Lalic, Nebojsa" sort="Lalic, Nebojsa" uniqKey="Lalic N" first="Nebojsa" last="Lalic">Nebojsa Lalic</name>
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<country name="Royaume-Uni"><noRegion><name sortKey="Walker, Mark" sort="Walker, Mark" uniqKey="Walker M" first="Mark" last="Walker">Mark Walker</name>
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Influence of the ACE Gene Insertion/Deletion Polymorphism on Insulin Sensitivity and Impaired Glucose Tolerance in Healthy Subjects

Influence of the ACE Gene Insertion/Deletion Polymorphism on Insulin Sensitivity and Impaired Glucose Tolerance in Healthy Subjects

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Abstract

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